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arsenic trioxide DRUG INTERACTIONS: See also the How to Use section. Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, s or change the dosage of any medicine before checking with them first. This drug should not be used with the following medications because very serious interactions may occur: bosentan, coal tar, live vaccines, tacrolimus. If you are currently using any of these medications, tell your doctor or pharmacist before starting cyclosporine. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: birth control pills, caspofungin, ezetimibe, drugs that worsen kidney problems (e.g., acyclovir, aminoglycoside antibiotics including tobramycin; amphotericin B; colchicine; fibrates including fenofibrate; melphalan; NSAIDs including diclofenac and sulindac; ranitidine; sulfa drugs including sulfamethoxazole; vancomycin), drugs affecting liver enzymes that remove cyclosporine from your system (such as allopurinol; amiodarone; azole antifungals including fluconazole and ketoconazole; barbiturates including phenobarbital; bromocriptine; calcium channel blockers including diltiazem, nicardipine, and verapamil; cimetidine; HIV protease inhibitors including indinavir; imatinib; macrolide antibiotics including erythromycin; certain man-made male hormones such as danazol and methyltestosterone; methylprednisolone; metoclopramide; metronidazole; nafcillin; nefazodone; octreotide; quinupristin/dalfopristin; rifamycins including rifampin; certain anti-seizure drugs including carbamazepine and phenytoin; St. Johns wort; ticlopidine), nifedipine, orlistat, sulfinpyrazone, temsirolimus, terbinafine, drugs that may increase potassium levels (e.g., ACE inhibitors including lisinopril, ARBs including losartan, potassium supplements, "water pill" including amiloride, spironolactone). This medication can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include aliskiren, digoxin, dronedarone, eoside, repaglinide, tolterodine, certain statins (atorvastatin, lovastatin, rosuvastatin, simvastatin), other immunosuppressants (such as azathioprine, methotrexate, sirolimus), among others. Do not use potassium-containing salt substitutes while taking this medication. Consult your doctor or pharmacist for more information. This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: breast cancer (males), prostate problems (such as cancer, enlarged prostate or BPH), liver problems, heart problems (such as heart failure, heart attack), stroke, kidney problems, diabetes, high cholesterol level, lung disease, obesity, difficulty breathing during sleep (apnea), high blood pressure, bone cancer, blood clots (such as in the leg, lungs). Cyclo-oxygenase is an enzyme that is involved in the production of various chemicals in the body, some of which are known as prostaglandins. Prostaglandins are produced in response to injury or certain diseases and cause pain, swelling and inflammation.

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HOW TO USE: Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. If you have any questions, ask your doctor, diabetes educator, or pharmacist. Learn all preparation and usage instructions from your health care professional and the product package. Before using, check this product visually for particles or discoloration. If either is present, do not use the insulin. Insulin regular should be clear and colorless. Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury under the skin and to avoid developing problems under the skin (lipodystrophy). Insulin regular may be injected in the stomach area, the thigh, the buttocks, or the back of the upper arm. Do not inject into a vein or muscle because very low blood sugar (hypoglycemia) may occur. Do not rub the area after the injection. Do not inject into skin that is red, swollen, or itchy. Do not inject cold insulin because this can be painful. The insulin container you are currently using can be kept at room temperature (see also Storage section). Inject this medication under the skin as directed by your doctor, usually 30 minutes before meals. Because this insulin is fast-acting, not eating right after a dose of this insulin may lead to low blood sugar (hypoglycemia). Giving insulin regular into a vein should only be done by a health care professional. Very low blood sugar may result. Do not use insulin regular in an insulin pump. This product may be mixed only with certain other insulin products such as NPH insulin. Always draw the insulin regular into the syringe first, then follow with the longer-acting insulin. Never inject a mixture of different insulins into a vein. Consult your health care professional about which products may be mixed, the proper method for mixing insulin, and the proper way to inject mixtures of insulin. Do not change brands or types of insulin without directions on how to do so from your doctor. Learn how to store and discard medical supplies safely. The dosage is based on your medical condition and response to treatment. Measure each dose very carefully because even small changes in the amount of insulin may have a large effect on your blood sugar levels. Check your urine/blood sugar level as directed by your doctor. Keep track of your results and share them with your doctor. This is very important in order to determine the correct insulin dose. Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day.

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MISSED DOSE: It is very important to follow your insulin regimen exactly. Ask your doctor ahead of time what you should do if you miss a dose of insulin.