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8. Stainer DW, et al. A simple chemically defined medium for the production of phase 1 Bordetella pertussis. J Gen Microbiol 1971;63:211-20.FIM are extracted and copurified from the bacterial cells. The pertussis antigens are purified by sequential filtration, salt-precipitation, ultrafiltration and chromatography. PT is detoxified with glutaraldehyde. FHA is treated with formaldehyde and the residual aldehydes are removed by ultrafiltration. The individual antigens are adsorbed separately onto aluminum phosphate.The 10 mL vial presentation contains the following inactive ingredients per mL: 30 mcg zinc, 2.7 mg m-cresol, 20 mg glycerol 85%, 20 mcg polysorbate 20, and water for injection. The 3 mL cartridge presentation contains the following inactive ingredients per mL: 30 mcg zinc, 2.7 mg m-cresol, 20 mg glycerol 85%, and water for injection.

3. Clifford DB, Evans S, Yang Y, et al. "Impact of efavirenz on neuropsychological performance and symptoms in HIV-infected individuals." Ann Intern Med 143 (2005): 714-21difficulty or pain when swallowing;The recommended dose of Sustiva for adults is 600 mg once a day. In patients aged three months to 17 years, the dose depends on body weight. For patients who are unable to swallow, the capsule contents can be mixed with a small amount of food (around two teaspoons). The dose of Sustiva needs to be reduced in patients taking voriconazole (used to treat fungal infections). Patients taking rifampicin (an antibiotic) may need to take a higher dose of Sustiva.

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