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Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Absorption and Distribution: Viagra is rapidly absorbed. Maximum observed plasma concentrations are reached within 30 to 120 minutes (median 60 minutes) of oral dosing in the fasted state. When Viagra is taken with a high fat meal, the rate of absorption is reduced, with a mean delay in Tmax of 60 minutes and a mean reduction in Cmax of 29%. The mean steady state volume of distribution (Vss) for sildenafil is 105 L, indicating distribution into the tissues. Sildenafil and its major circulating N-desmethyl metabolite are both approximately 96% bound to plasma proteins. Protein binding is independent of total drug concentrations.

In many of the studies, of both fixed dose and titration designs, daily diaries were kept by patients. In these studies, involving about 1600 patients, analyses of patient diaries showed no effect of Viagra on rates of attempted intercourse (about 2 per week), but there was clear treatment-related improvement in sexual function: per patient weekly success rates averaged 1.3 on 50–100 mg of Viagra vs 0.4 on placebo; similarly, group mean success rates (total successes divided by total attempts) were about 66% on Viagra vs about 20% on placebo.Many side effects are temporary for those who take Cialis?; however, some men have experienced an unsettled stomach, headache, back and muscle aches and pains. Most commonly, men experiencing these symptoms had relief within a few hours of taking the medication. For men suffering mainly from back and muscle pain, these side effects may appear 12 to 24 hours after taking the medication. Normally, there is not treatment required for these aches and pains as they tend to go away on their own sometime within 48 hours after taking Cialis?. Of course, as with any medication, if you experience any symptoms from Cialis? that do not subside or cause serious pain or worry, your doctor should be notified right away. cialis generic canada ?Qué debo evitar mientras tomo vardenafil?decreased visionHepatic

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