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Erection of the penis is initiated by the relaxation of smooth muscle in the corpus cavernosum, one of a pair of sponge-like regions in the penis. When aroused, nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum. Nitric oxide activates the enzyme guanylate cyclase resulting in increased synthesis of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the corpus cavernosum. The cGMP triggers smooth muscle relaxation, increasing blood flow into the penis, resulting in erection.BECAUSE SEXUAL ACTIVITY MAY PLACE A STRAIN ON YOUR HEART, YOUR DOCTOR WILL NEED TO CHECK WHETHER YOU ARE FIT ENOUGH TO TAKE VIAGRA. cialis once daily Critical revision of the manuscript for important intellectual content: All authors.Cialis

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Therefore when starting Cialis, patients must give all details of medicines being taken so that the doctor can plan the prescription accordingly.(N=476) Tadalafil 5 mg (N=151) Tadalafil 10 mg (N=394) Tadalafil 20 mg (N=635) alternative to cialis ? liver disease, kidney disease (or if you are on dialysis);Long-term safety information is not available on the concomitant administration of vardenafil with HIV protease inhibitors.

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In order for tadalafil to be effective for the treatment of erectile dysfunction, sexual stimulation is required. CIALIS for use as needed was shown to improve erectile function compared to placebo up to 36 hours following dosing. Therefore, when advising patients on optimal use of CIALIS, this should be taken into consideration.

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High blood pressure. Make sure your blood pressure is checked at least once a year. If it is high, it can be treated.Marketing(N=97)

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