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Penile erection is caused by the engorgement of the penis with blood. This engorgement occurs when the blood vessels delivering blood to the penis increase the delivery of blood and the blood vessels carrying blood away from the penis decrease the removal of blood. Under normal conditions, sexual stimulation leads to the production and release of nitric oxide in the penis. Nitric oxide then activates the enzyme, guanylate cyclase, which causes the production of cyclic guanosine monophosphate (cGMP). It is the cGMP that is primarily responsible for the erection by affecting the amount of blood that the blood vessels deliver and remove from the penis.
Figure 6: Mean IPSS Changes in BPH Patients by Visit in Study K cialis online order tenderness in the stomach area excessive itching and difficulty in breathing Endpoint [Change from baseline] 12.2 [0.1] 19.3 [6.4] 18.7 [7.3] <.001Sudden loss or decrease in hearing, sometimes with ringing in the ears and dizziness, has been rarely reported in people taking PDE5 inhibitors, including Cialis. It is not possible to determine whether these events are related directly to the PDE5 inhibitors, to other diseases or medications, to other factors, or to a combination of factors. If you experience these symptoms, stop taking Cialis and contact a healthcare provider right away.
Effects on Bleeding [see Warnings and Precautions (5.8)]Cialis is not indicated for use in women. buy sildenafil
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