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To address concern about the possible confounding of erectile function, we examined whether it was associated with risk of subsequent skin cancers. We conducted an analysis excluding users of sildenafil and other treatments for ED. For this analysis, men who did not report erectile function were further excluded. To clarify the association of sildenafil use with other cancers, we evaluated the risk of incident total nonskin cancers as well as major individual cancers, adjusting for age, body mass index, smoking, physical activity, UV index at birth and age 15 and 30 years, multivitamin use, physical examination in the last 2 years, and other treatments for ED.

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Sildenafil citrate is a white to off-white crystalline powder with a solubility of 3.5 mg/mL in water and a molecular weight of 666.7.Nervous system

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