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In vitro studies have shown that the effect of tadalafil is more potent on PDE5 than on other phosphodiesterases. These studies have shown that tadalafil is >10,000-fold more potent for PDE5 than for PDE1, PDE2, PDE4, and PDE7 enzymes, which are found in the heart, brain, blood vessels, liver, leukocytes, skeletal muscle, and other organs. Tadalafil is >10,000-fold more potent for PDE5 than for PDE3, an enzyme found in the heart and blood vessels. Additionally, tadalafil is 700-fold more potent for PDE5 than for PDE6, which is found in the retina and is responsible for phototransduction. Tadalafil is >9,000-fold more potent for PDE5 than for PDE8, PDE9, and PDE10. Tadalafil is 14-fold more potent for PDE5 than for PDE11A1 and 40-fold more potent for PDE5 than for PDE11A4, two of the four known forms of PDE11. PDE11 is an enzyme found in human prostate, testes, skeletal muscle and in other tissues (e.g., adrenal cortex). In vitro, tadalafil inhibits human recombinant PDE11A1 and, to a lesser degree, PDE11A4 activities at concentrations within the therapeutic range. The physiological role and clinical consequence of PDE11 inhibition in humans have not been defined. alcohol and viagra general feeling of discomfort or illnessSimilar to nitrates, alpha-blockers improve blood flow. This class of drug helps to keep blood vessels relaxed and open. Alpha-blockers can be used to treat high blood pressure. Because they help relax other parts of the body, they can also be used to help urine flow in men with prostate cancer. All three ED medications can further lower blood pressure if used with alpha-blockers. The National Institutes of Health (NIH) urges caution if using PDE-5 inhibitors along with alpha-blockers.Follow all directions given to you by your doctor or pharmacist carefully.Tadalafil and/or its metabolites cross the placenta, resulting in fetal exposure in rats.
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Siga todas las instrucciones en la etiqueta de su prescripción. No tome esta medicina en cantidades mayores o menores, o por más tiempo de lo recomendado.
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Do not take Viagra if you have an allergy to Viagra or similar medicines or any of the ingredients listed at the end of this leaflet Haematuria
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